Roche entered this race in 2024 when it acquired Carmot Therapeutics for $2.7 billion, gaining CT-388 (RO7690479), a dual GLP-1R/GIPR agonist with a distinct receptor profile
These findings are promising, but they need to be understood carefully
Common side effects include: Nausea (most common, usually improves over time) Vomiting or diarrhea Constipation Rarely, pancreatitis or gallbladder issues For a deeper dive into risks and what to watch for, see our dedicated guide: GLP-1 Side Effects Explained by Doctors
Spacing doses appropriately can minimize compound digestive upset
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But the advice on expired semaglutide is unanimous across specialties, across professional organizations, and across national health authorities